Which inflammatory factor is inhibited by both paracetamol and ibuprofen?

Paracetamol and ibuprofen both inhibit the production of prostaglandins, which are key inflammatory mediators. Prostaglandins play a significant role in promoting inflammation, fever, and pain. By reducing the levels of these compounds, both medications alleviate discomfort and reduce inflammation.

Paracetamol primarily acts in the central nervous system, influencing pain and temperature regulation, while ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that works peripherally to decrease prostaglandin synthesis. This shared action is why both drugs can effectively manage symptoms related to inflammation and pain.

In contrast, histamines, bradykinin, and cytokines are involved in other pathways related to the inflammatory response but are not directly inhibited by either paracetamol or ibuprofen in the same way as prostaglandins. This distinction highlights why the correct response is focused on the role of prostaglandins in the mechanism of action of both medications.